US 2026/0298890 A1Published application

Methods and Systems for Identifying Bioactive Compounds in Herbal Medicines Through Patient Response Analysis

OwnerJianyi Zhanginventor

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Abstract

Methods and systems are provided for identifying bioactive compounds in herbal medicines through analysis of patient responses. The method includes establishing objective, measurable clinical criteria for treatment effectiveness; treating patients with the selected herbal medicine; classifying patients as responders or non-responders based on the criteria; analyzing blood samples from both groups using liquid chromatography-mass spectrometry (LC-MS); identifying common elements (CEs) consistently present in responders; determining which non-responders lack one or more CEs; estimating required concentrations of missing CEs using pharmacokinetic principles; administering the missing or supplemental CEs to those non-responders; and confirming bioactivity if clinical improvement occurs. This approach links specific compounds to therapeutic efficacy, overcomes limitations of traditional isolation and screening, and reduces time and cost. The method applies to Traditional Chinese Medicine, Ayurvedic medicine, and other herbal systems with definable efficacy criteria and responsive patient populations.

Claims3

Dependent claims

A method for identifying bioactive compounds in herbal medicines, comprising:

(a) establishing objective clinical criteria for assessing treatment effectiveness, wherein said criteria are measurable and reproducible;
(b) selecting and preparing herbal medicines based on their traditional use for treating a specific medical condition;
(c) enrolling a population of patients with the target medical condition and administering the herbal medicine according to a defined treatment protocol;
(d) classifying patients as clinical responders who meet the pre-established criteria for clinical improvement, or as non-responders who do not meet said criteria;
(e) obtaining blood samples from both responders and non-responders at a pre-determined time point after herbal medicine administration;
(f) analyzing the blood samples using liquid chromatography-mass spectrometry (LC-MS) or other chemical instruments to identify chemical compounds present in each sample;
(g) identifying Common Elements (CEs) as chemical compounds present in all or substantially all clinical responders;
(h) analyzing blood samples from non-responders to determine which non-responders possess all identified CEs and which lack one or more CEs or with lower CEs;
(i) estimating the concentration of any missing CEs in the original herbal preparation using pharmacokinetic principles;
(j) administering the missing CEs or increased doses of CEs present at lower concentrations than those found in responders to non-responders lacking complete CEs or with lower CEs;
(k) re-evaluating treated patients against the pre-established clinical criteria;
(l) and confirming that the administered CEs are bioactive compounds if treated patients demonstrate clinical improvement meeting the pre-established criteria.

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