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US 2026/0298824 A1Published application
Nanowire array containing nonstick layer and methods of making and using therof for analyte detection
AssigneeAlignedBio AB
InventorsNiklas MÅRTENSSON, Søren ECHWALD, YuYu LI, Patrick FLATT
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Abstract
A nanowire array includes nanowires aligned with one another, and configured to bind with a target, and a nonstick layer surrounding fixed ends of the nanowires, the nonstick layer having a lower binding affinity with the target than the nanowires.
Claims20
A nanowire array, comprising:
- nanowires aligned with one another, and configured to bind with a target;
- and
- a nonstick layer surrounding fixed ends of the nanowires, the nonstick layer having a lower binding affinity with the target than the nanowires.
A sensing method, comprising:
- providing a nanowire array nanowires aligned with one another, capture molecules bound to the nanowires, and a nonstick layer surrounding fixed ends of the nanowires, the nonstick layer having a lower binding affinity with the capture molecules than the nanowires;
- providing an analyte fluid containing an analyte labeled with a fluorophore to the nanowire array;
- selectively binding the analyte labeled with the fluorophore to the capture molecules;
- exposing the array to source radiation;
- waveguiding emitted radiation from the fluorophores through the nanowires to a radiation detector;
- and
- determining a presence of the analyte in the analyte fluid based on detected emitted radiation.
4 more elements
A method of forming a nanowire array, comprising:
- providing a nanowire array comprising nanowires aligned with one another and a nonstick layer surrounding fixed ends of the nanowires;
- and
- providing target molecules to the nanowire array such that the target molecules selectively bind to the nanowires relative to the nonstick layer.
Dependencies are inferred from the claim text.