Heterodimeric Antibodies, Uses in Therapeutic Applications, and Compositions Related Thereto
OwnerEric SUNDBERG, Jonathan DU +1inventors
InventorsEric SUNDBERG, Jonathan DU, Tala AZZAM
Life of this patent
Estimating the term…
Abstract
Disclosed herein are mutant heavy chain antibody sequences. In certain embodiments, this disclosure contemplates heterodimeric antibodies with a first heavy chain and a second heavy chain, wherein the first and second heavy chain, or fragments thereof contain different mutations. In certain embodiments, this disclosure relates to nucleic acids and vectors encoding antibodies and recombinant heavy chains disclosed herein and cells containing the same.
Claims17
A recombinant antibody having a heavy chain with mutations K409S and T411Y.
A recombinant antibody having a heavy chain with mutations L368S and D399Y.
A recombinant antibody having a heavy chain with mutations D399Y and K447S.
A heterodimeric antibody comprising a first heavy chain with mutations K409S and T411Y and a second heavy chain.
Dependencies are inferred from the claim text.