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US 2026/0297181 A1Published application
Engineered antibody fusion proteins with modulable binding constants and their applications
AssigneeThe University of North Carolina at Chapel Hill
InventorsKoji SODE, Ellie WILSON
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Abstract
Compositions and methods of making engineered antibody fusion proteins with redox-sensitive domains with modulable binding affinity and devices for the continuous in vivo detection of target molecules are described.
Claims47
An engineered antibody fusion protein, the protein comprising a variable region of an immunoglobulin heavy chain (VH), a variable region of an immunoglobulin light chain (VL), and a redox-sensitive domain,
- wherein the redox-sensitive domain is capable of undergoing a conformational change upon exposure to an external signal, and
- wherein the conformational change modulates an affinity of the antibody fusion protein for a target molecule upon exposure to the external signal.
Dependencies are inferred from the claim text.