Insulin derivative and use thereof
AssigneeThe United Bio-Technology (Hengqin) Co., Ltd.
InventorsLiang HUANG, Xin XIE, Chunlai CAO, Cui ZHOU, Xiuyi HE, Huixing DENG, Xiaoxiao LIU
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Abstract
The present invention relates to the field of medicine and specifically provides insulin derivatives of formula (I) or salts or solvates thereof: The insulin derivative of formula (I) according to the present invention has better efficacy or effects, prolonged duration of action, and excellent bioavailability and safety.
Claims11
An insulin derivative of formula (I), or salts or solvates thereof:
- wherein,
- Z is CH3 or COOH;
- n is 17, 18, 19, 20 or 21;
- X is γGlu or absent;
- Y is —NH—(CH2)2—O—(CH2)2—O—CH2—CO—NH—(CH2)2—O—(CH2)2—O—CH2—CO—, or absent;
- R is the insulin parent body, wherein the ε-amino group of the lysine side chain at position 29 of the B-chain is connected to Y via an amide bond.
A pharmaceutical composition, comprising an effective amount of the insulin derivative of Formula (I), or salts or solvates thereof, and pharmaceutically acceptable adjuvants, diluents, carriers, or excipients.
Dependencies are inferred from the claim text.