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US 2026/0297032 A1Published application
Organic compound (oxime) to combat chemical warfare agents
AssigneePrepaire Labs Limited
InventorsCarl Freer, Vicente Jorge Ribas
Life of this patent
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Abstract
Described herein are compounds that reactivate acetylcholinesterase and associated methods of treating organophosphate poisoning.
Claims33
A compound of Formula (I), or a pharmaceutically acceptable salt thereof:
- wherein each R1 is independently selected from nitro and cyano;
- m is an integer from 0 to 5;
- R3 is selected from H and alkyl;
- X is selected from H, alkyl, heterocyclyl, aryl, cycloalkyl, and heteroaryl;
- or
- R3 and X, together with the carbon atom that separates them, complete a 4-6 membered heterocyclyl or cycloalkyl.
3 more elements
5-6. (canceled)
The compound of claim 5, having the structure of Formula (IA):
(canceled)
(canceled)
13-20. (canceled)
22-43. (canceled)
A compound of Formula (V), or a pharmaceutically acceptable salt thereof:
- wherein R1 is H or alkyl;
- and
- R2 is selected from aryl, heteroaryl, heterocyclyl, and cycloalkyl;
- or
- R1 combines with R2 to complete a 4-6 membered ring.
2 more elements
45-49. (canceled)
51-55. (canceled)
57-58. (canceled)
(canceled)
62-65. (canceled)
A compound of Formula (VII), or pharmaceutically acceptable salt thereof:
- wherein each R1 is independently selected from alkyl, cycloalkyl, halo, alkoxy, nitro, cyano, alkenyl, and alkynyl;
- R2 is selected from aryl, alkyl, heterocyclyl, heteroaryl, cycloalkyl, alkenyl, and alkynyl;
- and
- n is 0-6;
- or
- a compound of Formula (IX), or a pharmaceutically acceptable salt thereof:
- wherein each R3 is independently selected from alkyl, cycloalkyl, halo, alkoxy, nitro, cyano, alkenyl, and alkynyl;
- each R4 is independently selected from alkyl, cycloalkyl, halo, alkoxy, nitro, cyano, alkenyl, and alkynyl;
- x is 0-4;
- and
- y is 0-5.
8 more elements
67-69. (canceled)
72-73. (canceled)
77-78. (canceled)
Dependencies are inferred from the claim text.