Non-Peptide Small Molecule FGF14:Nav1.6 Channel Complex Protein-Protein Interaction Modulators

A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein:

• R1 is H, alkyl, alkoxy, halogen, cyano, amino, hydroxyl, NO2, CF3 or —OCF3;
• A is an aryl ring or a heteroaryl ring (e.g., pyridine), wherein ring A is fused to the C4 and C5 of the 5-membered N-heterocycle ring moiety of Formula I, e.g., as shown the compounds exemplified below;
• R2 is H, alkyl, alkoxy, halogen, —CO2R10, —CO2Me or hydroxyl;
• R3 is H, alkyl, alkoxy, halogen or hydroxyl;
• or R2 and R3 together form a 3-6 membered cycloalkyl ring;
• R4 is H, alkyl, alkoxy, halogen, cyano, hydroxyl or NT1T2;
• T1 is H, alkyl;
• T2 is independently chosen from:
• H, alkyl, cycloalkyl, benzyl, allyl, hydroxyl-alkyl;
• or T1 and T2 together form a 4-12 membered cycloalkyl ring or cycloheteroalkyl ring, wherein the 4-12 membered cycloalkyl ring or cycloheteroalkyl ring is optionally substituted with one or more groups selected independently from alkyl, cycloalkyl, alkenyl, aryl, heteroaryl, benzyl, alkoxy, halogen, cyan, nitro, amino, hydroxyl, CHF2, CF3 or —OCF3;
• n=0, 1, 2, 3, or 4;
• R5 is H, alkyl, aryl, cycloalkyl (e.g., is a bridged 6-14-membered bicyclic cycloalkyl, with 1-3 carbon length “bridge”);
• or heteroaryl, wherein each ring is optionally substituted with one or more groups selected independently from:
• H, alkyl, cycloalkyl, alkenyl, aryl, heteroaryl, benzyl, alkoxy (e.g., OMe, 3-OMe), halogen, cyano (e.g., 3-CN), nitro, amino, amido (e.g., 3-amido hydroxyl, —COOR8 (e.g., —COOMe), —CONHR9, CHF2, CF3 or —OCF3, wherein alkyl is optionally substituted with one or more substituents chosen from:
• hydroxyl, cyan, amino, or halogen;
• R6, and R7 are independently chosen from H, alkyl, F, CHF2, CF3, etc., or R6 and R7 taken together form a 3-7 membered ring (e.g., cyclopropane);
• R8 is independently chosen from:
• H, alkyl, aryl, cycloalkyl, benzyl;
• and
• R9 is independently chosen from:
• H, alkyl, aryl, cycloalkyl, benzyl, or substituted benzyl.
• R10 is alkyl (e.g., C1-C6-alkyl), aryl, or alkylaryl.