Implantable Composition For Use In Cartilage Defects Repair In Post-Surgery Rehabilitation
AssigneesFondazioneri, Med, The Children's Hospital of Philadelphia
InventorsRoberto DI GESU', Riccardo GOTTARDI
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Abstract
The invention relates to an implantable composition, comprising, as main components, a piezoelectric polymer loaded with magnetic micro-or nanoparticles and cellularized with stem cells, chondrocyte progenitors, or adult chondrocytes; the composition is useful in the post-surgery regenerative rehabilitation as part of the treatment of articular diseases caused by chondral defects (e.g. osteoarthritis).
Claims23
A biocompatible composition for use in implants in an area of the body subjected to surgery for the treatment of pathologies characterized from chondral defects, comprising:
- a) a matrix comprising a biocompatible polymer that is intrinsically piezoelectric, or a biocompatible polymer non-intrinsically piezoelectric loaded with an inorganic or organic filler imparting piezoelectric properties to the non-intrinsically piezoelectric polymer;
- b) between 1×105-1×109 nanoparticles/ml of a magnetic material;
- and
- c) between 1×105 and 1×108 cells chosen from the group consisting of mesenchymal stem cells, adult chondrocytes, and chondrocyte progenitors per milliliter of composition.
Dependencies are inferred from the claim text.