Biologically compatible, biofilm disrupting composition and methods

Abstract

A topical aqueous antibiofilm, antimicrobial, and antiviral composition to disrupt biofilm to enhance the killing of microbial and viral particles in a way that prevents and reduces the severity of conditions and infections that are due to such microbial pathogens and viral particles is provided. The composition comprises a fatty acid chosen from saturated and/or unsaturated medium chain fatty acids (MCFAs: C-8 to C-12), saturated and/or unsaturated long chain fatty acids (LCFAs: C-13 to C-26), and/or their derivatives, salts, sugars and esters. The composition also comprises a solubilizing agent, preferably a cyclodextrin, which additionally synergizes the antibiofilm effect, and may be formulated for nebulization/inhalation. The composition further comprises chelating and enhancing agents, and either a neutral, acid or alkaline pH. The composition comprises skin and mucosal permeation enhancers, which improve clinical efficacy. The composition comprises additional antimicrobial and antiviral compounds that can optionally be applied concomitantly.

Dependencies are inferred from the claim text.