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US 2026/0293880 A1Published application
Perfusion system for corneal endothelial cell graft evaluation
AssigneeRegents of the University of Minnesota
InventorsJoshua Honghan Hou, Ching Yuan, Sung Lee, Peter Bedard
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Abstract
Compositions, devices, and systems comprising a corneal tissue carrier, wherein the corneal tissue carrier comprises a corneal tissue sample and a fluid; wherein the fluid comprises resazurin. Additionally, methods including measuring cell viability.
Claims16
1-6. (canceled)
A method comprising:
- providing a corneal tissue carrier comprising:
- a corneal tissue sample;
- a first fluid solution;
- introducing a second fluid solution comprising resazurin into the corneal tissue carrier;
- incubating the corneal tissue carrier comprising the corneal tissue sample and the second fluid solution;
- removing the second fluid solution from the corneal tissue carrier;
- and
- collecting at least a portion of the second fluid solution.
5 more elements
A system comprising:
- a corneal tissue carrier comprising an inlet, an outlet, and a body portion tapered from the inlet toward the outlet;
- an input valve coupled to the corneal tissue carrier inlet and configured to control input of a first fluid solution and input of a second fluid solution to the corneal tissue carrier, wherein the first fluid solution comprises resazurin;
- an output valve coupled to the corneal tissue carrier outlet and configured to control output of fluid solution from the corneal tissue carrier;
- and
- a manipulation system coupled to the corneal tissue carrier and configured to control movement of the corneal tissue carrier.
2 more elements
Dependencies are inferred from the claim text.