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AssigneeHoffmann-La Roche Inc.
InventorsXing CHEN, Juergen GOTTOWIK, David HERZIG, Maryam OSKOUI, Mahnaz AMIRI PARIAN
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The present invention relates to methods computer-implemented method of monitoring a subject who has been diagnosed as having or likely to have a neuromuscular disease or disorder, the method comprising: obtaining movement data that has been collected by implementing a digital physiotherapy method; and determining, from said movement data, the value of one or more digital biomarkers, wherein the one or more digital biomarker values are indicative of a clinical measure of motor function. Related methods, systems and products are also described.
A computer-implemented method of monitoring a subject who has been diagnosed as having or likely to have a neuromuscular disease or disorder, the method comprising:
The method of any preceding claim, wherein the one or more digital biomarker values are selected from:
The method of any preceding claim, wherein determining the value of one or more digital biomarkers comprises determining the value of an arm functional workspace score as a value derived from the ranges of angles covered in the movement data from the subject by projections on the sagittal plane and the transverse plane of an arm vector, for one or both arms, optionally wherein the arm functional workspace score is the average of a value derived from the ranges of angles covered in the movement data from the subject by projections on the sagittal plane and the transverse plane of an arm vector, for each of a left and right arms.
The method of any preceding claim, wherein a value derived from the ranges of angles covered in the movement data from the subject by projections on the sagittal plane and the transverse plane of an arm vector is calculated as the percentage or the ratio between:
The method of any preceding claim, wherein determining the value of one or more digital biomarkers comprises determining the value of a head rotation range of motion score as a value derived from the range of the angle observed in movement data between a head forward vector and a torso forward vector, projected on the transverse plane, optionally wherein the head rotation range of motion is the ratio between (i) the range of the angle observed in the movement data between a head forward vector and a torso forward vector, projected on the transverse plane, and (ii) a maximum range of 180 degrees.
The method of any preceding claim, wherein determining the value of one or more digital biomarkers comprises determining the value of a hand flexion/extension range of motion as a value derived from the range of the angle observed in movement data between a palm vector and a finger vector, for one or both hands, optionally wherein the hand flexion/extension range of motion is the ratio between (i) the range of the angle observed in the movement data between a palm vector and a finger vector, and (ii) a maximum range of 180 degrees, optionally wherein the range of the angle observed in the movement data is the range between a 2nd, 5th or 10th percentile and a 90th, 95th or 98th percentile of a distribution of angle observed in the movement data between a palm vector and a finger vector.
The method of any preceding claim, wherein determining the value of one or more digital biomarkers comprises determining the value of a total functional workspace score (TFWS) as a linear or non-linear combination of:
The method of any preceding claim, wherein determining the value of one or more digital biomarkers comprises determining the value of a change in speed of movement of an upper limb part between a predetermined period of time at the start of a session of use of the digital physiotherapy method and a predetermined period of time at the end of the session and/or a change in an upper limb range of motion between a predetermined period of time at the start of a session of use of the digital physiotherapy method and a predetermined period of time at the end of the session, and combinations thereof,
The method of any preceding claim, wherein the plurality of sets of predetermined criteria comprise:
The method of any preceding claim, wherein the plurality of joints include one or more or all of a plurality of locations that aligns with a subject's:
The method of any preceding claim, wherein at least one criterion applies to an angle between two predetermined vectors derived from one or more joints or to the projection of an angle between two predetermined vectors on a predetermined body plane, and wherein the method comprises calibrating the at least one criterion by recording movement data of the subject while the subject is performing the movement associated with the predetermined criterion and identifying an expected range of the angle or the angle projection while the subject is performing the movement associated with the predetermined criterion.
The method of any preceding claim, wherein the plurality of sets of predetermined criteria comprise one or more of:
Dependencies are inferred from the claim text.