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US 2026/0286415 A1Published application
Methods and compositions for nucleic acid synthesis
AssigneePrimrose Bio, Inc.
InventorsHelge ZIELER, Dongxin Karen XU, Alan GREENER, Christopher SCHVARCZ
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Abstract
The present disclosure provides compositions and methods for using accessory proteins to increase the yield of full-length RNA, to decrease the amount of double stranded RNA, and to increase the efficiency of RNA produced by in vitro transcription.
Claims17
A method of performing in vitro transcription comprising the steps of
- (a) combining a single-subunit RNA polymerase (RNApol) molecule with a double-stranded DNA template and at least one accessory protein and
- (b) producing a transcript or a population of transcripts.
Dependencies are inferred from the claim text.