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US 2026/0285910 A1Published application
Compositions comprising mrnas encoding hiv-1 membrane proximal external region (mper) peptides
OwnerBarton F. HAYNES, Kevin O. SAUNDERS +4inventors
InventorsBarton F. HAYNES, Kevin O. SAUNDERS, Zekun MU, Rory HENDERSON, Drew WEISSMAN, Bette T. Korber
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Abstract
In certain aspects the invention provides HIV-1 immunogens, including one or more HIV-1 MPER peptides or HIV-1 envelope protein sequence comprising a MPER peptide for antibody induction. In some embodiments, the one or more HIV-1 MPER peptides or HIV-1 envelope protein sequence comprising a MPER peptide are encoded by mRNAs.
Claims21
A recombinant HIV-1 MPER peptide comprising all the consecutive amino acids after the signal peptide of SEQ ID NOs:
- 1, 2, or 16-45 or a HIV-1 envelope protein sequence comprising a MPER peptide comprising all the consecutive amino acids after the signal peptide of SEQ ID NOs:
- 46-107.
A nucleic acid sequence comprising SEQ ID NOs 108-159.
-44. (canceled)
Dependencies are inferred from the claim text.