Hydroxynorketamine analogues, compositions comprising same and methods of use thereof
AssigneeSpirify Pharma Inc.
InventorIrving William WAINER
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Abstract
The present disclosure pertains to amino cyclohexanone compounds, pharmaceutical compositions containing same and methods of treating depression, pain, inflammation, and other clinical indications.
Claims12
A method of treatment of a disease or condition selected from the group consisting of a mental disorder, Alzheimer's dementia, amyotrophic lateral sclerosis, inflammation, and pain, in a subject in need thereof, the method comprising administering a composition comprising an effective amount of a compound of Formula (I), a stereoisomer, or a pharmaceutically acceptable salt thereof
- R1 is —H, —OH, —N3, —SR4, —SO2R4, —NHR4, or —N(R4R5);
- R2 is —H, —CN, —N3, —SR4, —SO2R4, —NHR4, or —N(R4R5);
- wherein R4 and R5 are independently selected from C1-C8 saturated or unsaturated alkyl;
- when R1 is —OH, R2 is —H, and R3 is
- when R1 is —N3, —SR4, —SO2R4, —NHR4, or —N(R4R5), R2 is —H, and R3 is
- when R1 is —H, R2 is —CN, —N3, —SR4, —SO2R4, —NHR4, or —N(R4R5);
- and
- R3 is
A method of inhibiting N-methyl-D-aspartate (NMDA) receptor activity, modifying endogenous concentrations of D-Serine, stimulating the phosphorylation of mammalian target of rapamycin (mTOR), inhibiting nicotinic acetylcholine receptor (nAChR) activity, inhibiting serine racemase (SR), or inhibiting or attenuating proinflammatory agents secretion from immune cells, the method comprising contacting cells with an effective amount of a compound of Formula (I), a stereoisomer, or a pharmaceutically acceptable salt thereof
- R1 is —H, —OH, —N3, —SR4, —SO2R4, —NHR4, or —N(R4R5);
- R2 is —H, —CN, —N3, —SR4, —SO2R4, —NHR4, or —N(R4R5);
- wherein R4 and R5 are independently selected from C1-C8 saturated or unsaturated alkyl;
- when R1 is —OH, R2 is —H, and R3 is
- when R1 is —N3, —SR4, —SO2R4, —NHR4, or —N(R4R5), R2 is —H, and R3 is
- when R1 is —H, R2 is —CN, —N3, —SR4, —SO2R4, —NHR4, or —N(R4R5);
- and
- R3 is
Dependencies are inferred from the claim text.