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US 2026/0285798 A1Published application
Methods for making and using endoxifen
AssigneeAtossa Therapeutics, Inc.
InventorsSteven C. Quay, Yao-Lin Sun, LungHu Wang, ChangJung Wu, ChuanDer Huang
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Abstract
The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.
Claims35
A controlled-release composition comprising:
- a compound of Formula (III):
- or a pharmaceutically acceptable salt thereof, wherein at least 90 wt % of the compound of Formula (III) is (Z)-endoxifen;
- and
- from 0.01 wt % to 3 wt % of a control release agent.
1 more element
A method of treating a disease or disorder in a subject in need thereof, the method comprising administering to the subject in need thereof a controlled-release composition comprising:
- a compound of Formula (III):
- or a pharmaceutically acceptable salt thereof, wherein at least 90 wt % of the compound of Formula (III) is (Z)-endoxifen;
- and
- from 0.01 wt % to 3 wt % of a control release agent,
- thereby treating the disease or disorder in the subject in need thereof.
2 more elements
Dependencies are inferred from the claim text.