Intravascular blood pump systems and methods of use and control thereof

A fluid control system for an intravascular blood pump, comprising:

• an external console including
• a fluid cassette compartment
• a pump head comprising a plurality of rollers, and
• a plurality of flow control actuators adapted to be independently controlled and independently moved toward the fluid cassette compartment;
• and
• a removable fluid cassette, sized and configured to fit within the fluid cassette compartment and to be stabilized therein in at least one direction, the fluid cassette including a plurality of fluid pathways that are each accessible from a first side of the cassette at a plurality of access locations, wherein each one of the plurality of flow control actuators is aligned with one of the plurality of access locations when the fluid cassette is in a closed state to allow each of the flow control actuators to engage one of the plurality of fluid pathways and control the flow of fluid therethrough.