Self-Polymerizing, Radiopaque Resin For Percutaneous Vertebroplasty

Abstract

In various embodiments, the present invention relates to a solvent-free polymer system using poly(allyl glycidyl ether succinate) (PAGES) for vertebral augmentation. PAGES crosslinks in situ through thiol-ene click chemistry with a cure time at 37° C. ranging from 17 to 53 minutes based on degree of polymerization and crosslinker concentration. The addition of SrCO3 increased the ultimate compressive strength (σmax) of the PAGES composite to 4.4±0.4 MPa. Furthermore, the addition of SrCO3 increases osteoblast proliferation and differentiation of mesenchymal stem cells seeded onto the surface of PAGES composite. Finally, the compressive strength of fractured rabbit vertebra was increased ex vivo when filled with the PAGES composite demonstrating its potential as a bone augmentation material.

Dependencies are inferred from the claim text.