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US 2026/0284194 A1Published application
Photodynamic therapy composition
OwnerJames Basilioninventor
Life of this patent
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Abstract
A photodynamic therapy composition, the composition includes a plurality of targeted phthalocyanine gold nanoparticle conjugates, wherein each targeted phthalocyanine gold nanoparticle conjugate includes a plurality of phthalocyanine compounds covalently coupled to a surface of the gold nanoparticle via bio-cleavable linker and a plurality of cancer or tissue targeting agents coupled to the gold nanoparticle.
Claims20
A photodynamic therapy composition comprising:
- a plurality of targeted phthalocyanine gold nanoparticle conjugates, wherein each targeted phthalocyanine gold nanoparticle conjugate includes a plurality of phthalocyanine compounds covalently coupled to a surface of the gold nanoparticle via bio-cleavable linkers and a plurality of cancer or tissue targeting agents coupled to the gold nanoparticle.
A method for treating a PSMA expressing cancer in a subject in need thereof, the method comprising:
- (a) administering systemically to the subject therapeutically effective amount of a photodynamic therapy composition, the photodynamic therapy composition including a plurality of targeted phthalocyanine gold nanoparticle conjugates, wherein each targeted phthalocyanine gold nanoparticle conjugate includes a plurality of phthalocyanine compounds covalently coupled to a surface of the gold nanoparticle via bio-cleavable linker and a plurality of PSMA ligands coupled to the gold nanoparticle;
- and
- (b) exposing the phthalocyanine compounds to near infrared (NIR) light, thereby inducing the cytotoxic effects of the phthalocyanine compound.
A method for treating a PSMA expressing cancer comprising:
- (a) administering systemically to the subject therapeutically effective amount of a photodynamic therapy composition, the photodynamic therapy composition including a plurality of targeted phthalocyanine gold nanoparticle conjugates, wherein each targeted phthalocyanine gold nanoparticle conjugate includes a plurality of phthalocyanine compounds covalently coupled to a surface of the gold nanoparticle via bio-cleavable linker and a plurality of PSMA ligands coupled to the gold nanoparticle;
- and
- (b) exposing the phthalocyanine compound to near infrared (NIR) light, thereby inducing the cytotoxic effects of the phthalocyanine compound, wherein NIR light is sequentially administered at least three times following administration of the photodynamic therapy composition to the subject, and wherein each NIR administration results in increased photodynamic therapy composition accumulation in the subject's cancer cells.
Dependencies are inferred from the claim text.