Polq inhibitors

A compound of formula (I).

• or a stereoisomer or pharmaceutically salt thereof;
• wherein,
• R1 and R2 are each, independently, H, halo, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 haloalkyl, C1-C3 hydroxyalkyl, —CN, C2-C4 alkyne, or C2-C6 alkoxyalkyl;
• Q1, Q2, and Q3 are, independently N, C-L-R, or CRx, wherein no more than one of Q1, Q2, and Q3 is C-L-R;
• L is a bond, —O—;
• —C(O)—;
• —O(CH2)pC(O)—;
• —C(O)NR—;
• —O(CH2)pC(O)NR—;
• —O(CH2)pNR3;
• NRy—;
• —(CH2)p—;
• (CH2)pNRy—;
• —(CH2)pO—;
• —(CH2)pC(O)—;
• —(CH2)pC(O)O—;
• or —O(CH2)p—;
• p is, independently, 1, 2, or 3
• R is H, Ra, Rb, Rc, or Rd;
• Ra is a 3-10 membered heterocycle optionally substituted with 1 to 4 substituents independently selected from amino, carboxy, halo, hydroxy, oxo, —CN, —S(O)2OH, C1-C4 alkylamino, C1-C5 alkoxy, C2-C5 alkoxyalkyl, 4-6 membered heterocycle, and C1-C7 alkyl, wherein the C—C7 alkyl is optionally substituted with 1 to 4 substituents independently selected from amino, carboxy, halo, hydroxy, oxo, —CN, C2-C8 ester, and C1-C8alkoxy;
• Rb is a C1-C7 alkyl, wherein one or two methylene groups from the C1-C7 alkyl are optionally independently replaced with NRc or O and one or two single bonds in a C2-C7 alkyl chain are optionally independently replaced with a double or triple bond(s),
• wherein the C1-C7 alkyl is optionally substituted with 1 to 4 substituents independently selected from:
• halo, oxo, hydroxy, carboxyl, amino, —CN, C2-C4 alkynyl, C2-C6 carbamate, C1-C8 amide, C1-C4 sulfonyl, C1-C4 sulfonamide, C1-C4 alkylamino, C1-C5 alkoxy, C3-C6 carbocycle, and 3-10 membered heterocycle,
• wherein the C3-C6 carbocycle is optionally substituted with 1 to 4 substituents independently selected from hydroxy, halo, and carboxy;
• wherein the 3-10 membered heterocycle is optionally substituted with 1 to 4 substituents independently selected from amino, carboxy, halo, hydroxy, oxo, —CN, —S(O)2OH, C1-C4 alkylamino, C1-C5 alkoxy, C2-C5 alkoxyalkyl, 4-6 membered heterocycle, and C1-C7 alkyl, wherein the C1-C7 alkyl is optionally substituted with 1 to 4 substituents independently selected from amino, carboxy, halo, hydroxy, oxo, —CN, C2-C8 ester, and C1-C3 alkoxy;
• Rc is a C3-C6 carbocycle optionally substituted with 1 to 4 substituents independently selected from hydroxy halo, and carboxy;
• Rd is C1-C4 sulfonyl or C1-C4 sulfonamide;
• Ry is H, C1-C3 alkyl, or C1-3 haloalkyl;
• Rx is H, halo, hydroxy, —CN, —NH2, C1-C3 alkoxy, C1-C3 alkyl, or C1-C8 haloalkyl;
• Rc is H, halo, C1-C8 alkyl, or C1-C8 haloalkyl;
• X is a C1-C4 alkylene;
• Y is a phenyl or 5-6 membered heteroaryl, wherein the phenyl or heteroaryl is optionally substituted with 1-3 substituents independently selected from halo, C1-C3 alkyl, C1-C3 alkoxy, —CN, C1-C3 haloalkyl, and cyclopropyl;
• G is N or CH;
• Ga and Gb are N, CH, or CR5 wherein one, and only one, of Ga and Gb is N or CH and one, and only one, of Ga and G, is CR5;
• R5 is
• Za and Zb are, independently, C1-C3 alkyl or C1-C3 haloalkyl, or Za and Zb form a 3-6 membered carbocycle or heterocycle;
• and
• Zc is H, —CN, C1-C3 alkyl, C1-C3 haloalkyl, or C2-C4 alkyne.