Compounds for restoring susceptibility to beta-lactam antibiotics

A compound of formula I:

• wherein,
• is a double bond or a single bond;
• Ya is
• wherein Xa is SG3, H, halo, N(G1)2, SO2G2, or —CH2R6;
• G1 is each independently H, —(C1-C6)alkyl, Boc, or Cbz;
• G2 is halo, OH, N(G1)2, —(C1-C6)alkyl, or —CH2Ar;
• G3 is —CH2R7, H, —(C1-C6)alkyl, —(C1-C6)alkenyl, N(G1)2, or Ar;
• G4 is OH, N(G1)2, or —O(C1-C6)alkyl;
• Ar is a phenyl substituted with —O(C1-C6)alkyl;
• R1a and R1b taken together with the carbon atoms to which they are attached in formula I form a benzo ring substituted with R1c;
• or
• R1a is H, CN, —C(═O)G4, —CH2N(G1)2, or —(C1-C6)alkyl substituted with one or more OR2c;
• and
• R1b is H, halo, or —(C1-C6)alkyl;
• R1c is CN, H, —C(═O)G4, —CH2OR2c, —CH2N(G1)2, —CH2N(G1)COCH3, or —CH2N(G1)CO(Yb)Ph, wherein Ph is substituted with R5a and/or R5b, and Yb is —CH═CH— or —CH2CH2—;
• R2a and R2b are each independently CF3, H, halo, SF5, or —(C1-C6)alkyl optionally substituted with one or more halo;
• R2c is each independently H or —(C1-C6)alkyl;
• R4 is a lone pair when Ya is
• and is a double bond;
• or
• R4 is H or —(C1-C6)alkyl when Ya is
• and is a single bond;
• R5a and R5b are each independently H, halo, CF3, SF5, or —(C1-C6)alkyl optionally substituted with one or more halo;
• R6 is halo, OR2c, —CH2OR2c, B(OR2c)2, —CH2B(OR2c)2, B(pinanediol), —CH2B(pinanediol), or
• and
• R7 is B(OR2c)2, B(MIDA), Ar, or —(CH2)nCN wherein n is 1 to 6,
• or a pharmaceutically acceptable salt thereof.