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US 2026/0283965 A1Published application
Pharmaceutically active compositions and uses thereof
AssigneeXerient Pharma Ltd.
InventorsMichael Shtein, Guy Yachin, Galia Temtsin-Krayz, Dannit Licht, Pavel Kazhdan, Ofer Doron
Life of this patent
Estimating the term…
Abstract
The disclosure relates to pharmaceutical compositions of active pharmaceutical ingredients (API), for example—cytoprotective pro-drugs and uses thereof. More specifically, the disclosure is related to compositions, methods and uses of cytoprotective pro-drug microcapsules in a dispersion, or as micro-pellets, micro-beadles, micro-granules or mini tablets, all configured to activate upon exposure to a triggering event.
Claims24
A pharmaceutical dispersion comprising:
- a) a dispersed phase comprising:
- a plurality of controlled-release microcapsules, micro-pellets, micro-beadles, micro-granules or mini tablets comprising a cytoprotective pro-drug or an active pharmaceutical agent (API), and an activating agent;
- and
- b) a continuous phase comprising a hydrocolloid matrix configured, upon exposure to a predetermined event, to allow contact between the plurality of controlled-release microcapsules comprising the cytoprotective pro-drug or the active pharmaceutical agent, and the activating agent.
1 more element
Use of a pharmaceutical dispersion comprising:
- a dispersed phase comprising:
- a plurality of controlled-release microcapsules, micro-pellets, micro-beadles, micro-granules or mini tablets comprising a cytoprotective pro-drug or an active pharmaceutical agent (API), and an activating agent;
- and a continuous phase comprising a hydrocolloid matrix configured, upon exposure to a predetermined event, to allow contact between the plurality of controlled-release microcapsules comprising the cytoprotective pro-drug or the API, and the activating agent, in the process irradiating a tumor associated with:
- colorectal cancer, prostatic cancer, ovarian cancer, cervical cancer, or esophageal cancer.
1 more element
Dependencies are inferred from the claim text.