Loading patent…
AssigneeSmilebiotek Zhuhai Limited
InventorsYan ZHANG, Lai WEI, Hui OUYANG
Estimating the term…
Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
A method of treating age-related macular degeneration (AMD) in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from compounds 1-8, or a pharmaceutically acceptable salt thereof, wherein compounds 1-8 have the following chemical structure:
A method of reducing a drusenoid lesion and/or drusen-like nodules in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from compounds 1-8, or a pharmaceutically acceptable salt thereof, wherein compounds 1-8 have the following chemical structure:
A method of reducing activation of the complement system and/or inflammation in an eye in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from compounds 1-8, or a pharmaceutically acceptable salt thereof, wherein compounds 1-8 have the following chemical structure:
Dependencies are inferred from the claim text.