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US 2026/0276648 A1Published application
Upregulated metabolite found in brain cancer
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, Board of Regents, The University of Texas System
InventorsKalil G. Abdullah, Sam McBrayer
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Abstract
Methods for identifying tumor tissue and determining a margin of a tumor to be resected in a subject are disclosed within. The methods utilize guanidinoacetic acid (GAA) as a tissue biomarker of malignant brain tumors. The presently disclosed subject matter further relates to methods for providing a diagnosis or prognosis about a cancer in a subject.
Claims20
A method for resecting tumor tissue in a subject in need thereof, comprising:
- a) collecting one or more samples from a suspected tumor tissue;
- b) determining the level of guanidinoacetic acid (GAA) in the one or more samples;
- c) comparing the level of GAA in the one or more samples to a reference level;
- d) defining the suspected tumor tissue as tumor based on the level of GAA in the one or more samples;
- and
- e) resecting the suspected tumor tissue from the subject where the suspected tumor tissue is defined as tumor.
3 more elements
Dependencies are inferred from the claim text.