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US 2026/0276628 A1Published application
Compositions and methods for individualized characterization of non-ige mediated food allergies
AssigneeThe Regents of the University of Michigan
InventorsMohamad El Zaatari, John Y. Kao
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Abstract
Provided herein are compositions and methods for the individualized identification of triggers allergies (e.g., non-IgE mediated allergies) in an individual. In particular, biomarkers and assays are provided and used to characterize food allergies and related conditions (e.g., food protein-induced enterocolitis syndrome (FPIES), eosinophilic esophagitis (EoE), etc.) in an individual, by identifying safe and trigger foods without the need for oral challenge.
Claims1
A method of assessing the allergic sensitivity of a subject to an item comprising:
- (a) growing cells from the subject in growth media in contact with the item;
- (b) detecting the expression level in the cells of one or more biomarkers of allergic sensitivity;
- (c) comparing the expression level of the one or more biomarkers to threshold and/or control levels of expression;
- and
- (d) determining whether the item is a safe substance or trigger substance.
2 more elements
Dependencies are inferred from the claim text.