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AssigneeIcahn School of Medicine at Mount Sinai
InventorsPeter PALESE, Adolfo GARCIA-SASTRE, Florian KRAMMER
Estimating the term…
In one aspect, provided herein are recombinant neuraminidases comprising an ectodomain of influenza virus neuraminidase with amino acid substitutions or insertions of cysteines in the stalk domain to generate a more stable, tetrameric influenza virus neuraminidase. In specific embodiments, the influenza virus neuraminidase further comprises influenza virus neuraminidase transmembrane and cytoplasmic domains. In another aspect, provided herein are recombinant neuraminidase comprising a globular head domain of influenza virus neuraminidase and a tetramerization domain, wherein the recombinant neuraminidase lacks influenza virus neuraminidase stalk, transmembrane and cytoplasmic domains. In another aspect, provided herein are methods of immunizing against influenza virus using such recombinant neuraminidases or compositions thereof.
-49. (canceled)
A method of immunizing against influenza virus or preventing an influenza virus disease, comprising administering to a subject a dose of an immunogenic composition comprising a recombinant neuraminidase, wherein the recombinant neuraminidase comprises:
A method of inducing an immune response against influenza virus, comprising administering a subject a dose of an immunogenic composition comprising a recombinant neuraminidase, wherein the recombinant neuraminidase comprises:
(canceled)
A method of immunizing against influenza virus or preventing an influenza virus disease, comprising administering to a subject a dose of an immunogenic composition comprising a recombinant influenza virus, wherein the recombinant influenza virus comprises:
Dependencies are inferred from the claim text.