Immortalization of amnion-derived multipotent progenitor cell and uses thereof
AssigneeNoveome Biotherapeutics, Inc.
InventorsHedvika DAVIS, Randall RUPP, Ashley ELLIS, Christine SMITH
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Abstract
An immortalized amnion-derived multipotent progenitor (AMP) cell or cell line and methods of producing same. The immortalized AMP cells secrete a secretome (ST266*), in a highly scalable, cost-effective manner. The immortalized AMP cells may be proliferated in serum-free medium without the presence of HSA and EGF. Provided herein are compositions obtained from the secretome collected from at least one immortalized AMP cell.
Claims24
An immortalized amnion-derived multipotent progenitor (AMP) cell.
A composition comprising at least one immortalized AMP cell and a secretion of the at least one immortalized AMP cell.
A cell culture comprising a plurality of immortalized AMP cells.
A method for the production of an immortalized AMP cell, the method comprising:
- providing an isolated non-immortalized AMP cell;
- immortalizing the isolated non-immortalized AMP cell;
- and
- generating at least one immortalized monoclonal AMP cell line.
An immortalized amnion-derived multipotent progenitor (AMP) cell line selected from clones of single cells expressing PB-E6-E7-PB-TERT.
Dependencies are inferred from the claim text.