Anti-new york esophageal squamous cell carcinoma 1 (ny-eso-1) antigen-binding proteins and methods of use thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsKevin A. Bray, Frank Delfino, David Dilillo, Matthew C. Franklin, Jessica Kirshner, Douglas MacDonald
Life of this patent
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Abstract
The present disclosure provides antigen-binding proteins that specifically bind to an HLA-displayed New York esophageal squamous cell carcinoma 1 (NY-ESO-1) peptide, and therapeutic and diagnostic methods of using those binding proteins.
Claims19
-46. (canceled)
An isolated polynucleotide molecule comprising a polynucleotide sequence that encodes a heavy chain variable region (HCVR) of an antibody, or antigen-binding portion thereof, that binds specifically to at least one amino acid of an HLA-A2:
- New York esophageal squamous cell carcinoma 1 peptide (NY-ESO-1 peptide) complex,
- wherein the HCVR comprises a heavy chain complementarity determining region (HCDR) 1 of SEQ ID NO:
- 4, an HCDR2 of SEQ ID NO:
- 6, and an HCDR3 of SEQ ID NO:
- 8.
An isolated polynucleotide molecule comprising a polynucleotide sequence that encodes a light chain variable region (LCVR) of an antibody, or antigen-binding portion thereof, that binds specifically to at least one amino acid of an HLA-A2:
- New York esophageal squamous cell carcinoma 1 peptide (NY-ESO-1 peptide) complex,
- wherein the LCVR comprises a light chain complementarity determining region (LCDR) 1 of SEQ ID NO:
- 12, an LCDR2 of SEQ ID NO:
- 14, and an LCDR3 of SEQ ID NO:
- 16.
-75. (canceled)
An isolated polynucleotide molecule comprising a polynucleotide sequence of SEQ ID NO:
- 3, a polynucleotide sequence of SEQ ID NO:
- 5, and a polynucleotide sequence of SEQ ID NO:
- 7.
An isolated polynucleotide molecule comprising a polynucleotide sequence of SEQ ID NO:
- 11, a polynucleotide sequence of SEQ ID NO:
- 13, and a polynucleotide sequence of SEQ ID NO:
- 14.
Dependencies are inferred from the claim text.