Real-time monitoring of histotripsy dose delivery damage spatially and temporally
OwnerZhen XU, Jonathan R. SUKOVICH +2inventors
InventorsZhen XU, Jonathan R. SUKOVICH, Timothy L. HALL, Scott HASKELL
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Abstract
A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Systems and methods are provided which facilitate real-time monitoring of dose delivered and tissue ablation. The techniques can include monitoring received acoustic cavitation emission signals or using dMRI.
Claims24
A method of using a transmit-receive histotripsy system for histotripsy treatment monitoring, comprising the steps of:
- transmitting high-voltage histotripsy therapy pulses into a focal location within a target tissue with transmit electronics and a histotripsy therapy transducer array to generate cavitation in the focal location;
- receiving low-voltage acoustic cavitation emission (ACE) signals from the cavitation with receive electronics and the histotripsy therapy transducer array;
- processing the received ACE signals to identify a cavitation lifespan of the cavitation at the focal location;
- and
- identifying a plateau in the cavitation lifespan to determine that complete cellular disruption has occurred at the focal location.
A histotripsy system, comprising:
- an ultrasound transducer array;
- transmission electronics coupled to the ultrasound transducer array and configured to transmit one or more histotripsy pulses to one or more focal locations generate cavitation in a target tissue;
- receive electronics configured to receive acoustic cavitation emissions (ACE) from the cavitation;
- and
- one or more processors operatively coupled to the transmission and receive electronics, the one or more processors being configured to process the received ACE signals to identify a cavitation lifespan of the cavitation at the focal location and being further configured to identify a plateau in the cavitation lifespan to determine that complete cellular disruption has occurred at the focal location.
A method of monitoring histotripsy treatment, comprising the steps of:
- transmitting high-voltage histotripsy therapy pulses into one or more focal locations within a target tissue with transmit electronics and a histotripsy therapy transducer array to generate cavitation in the focal location;
- obtaining periodic diffusion weighted magnetic resonance imaging (dMRI) images of the one or more focal locations in the target tissue;
- processing the dMRI images to identify apparent diffusion coefficients (ADC) in the one or more focal locations in the target tissue;
- and
- generating an ADC map that conveys a dose of histotripsy therapy received at each of the one or more focal locations in the target tissue.
-42. (canceled)
Dependencies are inferred from the claim text.