Method of Enhancing Dihydromyricetin (DHM) Bioavailability

Abstract

A composition and method for naturally enhancing the bioavailability, efficacy, and potency of dihydromyricetin (DHM) without altering its chemical structure. By combining DHM with lemon-derived components within defined pH ranges, superior solubility, stability, and oral exposure compared to DHM alone or citric acid formulations can be achieved. Preclinical data demonstrate increased plasma concentration, improved pharmacokinetics, and enhanced functional efficacy. This provides a reproducible and broadly applicable method for improving therapeutic outcomes in anxiety, sleep disturbance, cognitive impairment, and Alzheimer's disease.

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