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AssigneeArcturus Therapeutics, Inc.
InventorsPattraranee Limphong, Carlos G. Perez-Garcia, Kiyoshi Tachikawa, Padmanabh Chivukula, Arisa Cale, Angel I-Jou Leu, Jared Davis
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This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.
A synthetic mammalian mRNA expression construct for producing a protein or polypeptide, the synthetic mammalian mRNA expression construct comprising a 5′ UTR, wherein the 5′ UTR comprises a 5′ UTR sequence of SynK, Human Albumin, Mouse Beta Globin, or Human Antithrombin mRNA.
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A synthetic mammalian mRNA expression construct for producing a protein or polypeptide, the synthetic mammalian mRNA expression construct comprising a 3′ UTR, wherein the 3′ UTR comprises a 3′ UTR sequence of Human Growth Factor, Mouse Albumin, Human Alpha Globin, Human Antithrombin, Human Complement C3, and Human Apolipoprotein E.
Dependencies are inferred from the claim text.