Combination of an atp-hydrolyzing enzyme and an immune checkpoint modulator and uses thereof
AssigneesMv Biotherapeutics SA, Institute for Research in Biomedicine
InventorsFabio GRASSI, Benedetta DE PONTE CONTI
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Abstract
The present invention provides a combination of (i) an immune checkpoint modulator and (ii) an ATP hydrolyzing enzyme, a nucleic acid encoding an ATP hydrolyzing enzyme, or host cells, microorganisms or viral particles comprising such nucleic acids encoding an ATP hydrolyzing enzyme. The combination may be used in medicine, in particular in the treatment of cancer, for example in cancer immunotherapy.
Claims37
A method for reducing the risk of occurrence, treating, ameliorating, or reducing cancer or initiating, enhancing or prolonging an anti-tumor-response in a subject in need thereof, comprising administering to the subject a combination of
- (i) an immune checkpoint modulator;
- and
- (ii) (a) an ATP hydrolyzing enzyme,
- (b) a nucleic acid comprising a polynucleotide encoding the ATP hydrolyzing enzyme,
- (c) a host cell comprising the nucleic acid,
- (d) a microorganism comprising the nucleic acid, or
- (e) a viral particle comprising the nucleic acid
- wherein the ATP hydrolyzing enzyme is apyrase.
A combination of
- (i) an immune checkpoint modulator;
- and
- (ii) an ATP hydrolyzing enzyme, wherein the ATP hydrolyzing enzyme is apyrase,
- (iii) a nucleic acid comprising a polynucleotide encoding the ATP hydrolyzing enzyme,
- (iv) a host cell comprising the nucleic acid,
- (v) a microorganism comprising the nucleic acid, or
- (vi) a viral particle comprising the nucleic acid.
A kit comprising:
- (i) an immune checkpoint modulator;
- and
- (ii) (a) an ATP hydrolyzing enzyme,
- (b) a nucleic acid comprising a polynucleotide encoding the ATP hydrolyzing enzyme,
- (c) a host cell comprising the nucleic acid,
- (d) a microorganism comprising the nucleic acid, or
- (e) a viral particle comprising the nucleic acid,
- wherein the ATP hydrolyzing enzyme is apyrase.
Dependencies are inferred from the claim text.