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US 2026/0265328 A1Published application
Therapeutic interferon alpha 1 proteins
AssigneeOrionis Biosciences BV
InventorsNikolai KLEY, Erik DEPLA, Lennart ZABEAU, Jan TAVERNIER
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Abstract
The present invention relates, in part, to chimeric proteins or chimeric protein complexes, such as Fc-based chimeric protein complexes, comprising interferon alpha 1, or a variant thereof, and their use as therapeutic agents.
Claims21
A chimeric protein comprising:
- (a) an interferon alpha 1 (IFNα1) or a variant thereof, and
- (b) one or more targeting moieties, said targeting moieties comprising recognition domains which specifically bind to an antigen or receptor of interest;
- wherein the IFNα1 or the variant thereof, and the one or more targeting moieties are optionally connected with one or more linkers.
-134. (canceled)
Dependencies are inferred from the claim text.