3-alkylamine indole activators of serotonin receptors
OwnerTanweer A. KHAN, Glenn F. SHORT +1inventors
InventorsTanweer A. KHAN, Glenn F. SHORT, Robert B. PERNI
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Abstract
Provided herein are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, A, B, and E are defined herein. Also provided are pharmaceutical compositions comprising a compound of Formula (I) and Formula (II) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) and Formula (II) or pharmaceutically acceptable salt thereof, e.g., in the treatment of a mental health disease or disorder.
Claims78
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- R1, R2, R6, R7, and independently are hydrogen, deuterium, alkyl, deuterated alkyl, heteroalkyl, haloalkyl, cycloalkyl, or heterocyclyl;
- R4, R5, R8, and R9 independently are hydrogen, deuterium, alkyl, heteroalkyl, haloalkyl, cycloalkyl, CO2R11, CONHR11, CO2N(R11)(R12), CN, or halogen,
- wherein R11 and R12 independently are hydrogen, deuterium, heteroalkyl, haloalkyl, cycloalkyl, or heterocyclyl;
- R10 is hydrogen, deuterium, or alkyl;
- A is C or N;
- B is CR13, N, or CO,
- wherein R13 is hydrogen, deuterium, alkyl, heteroalkyl, haloalkyl, cycloalkyl, or heterocyclyl;
- E is CR3, NR3, N, O, or S;
- wherein R3 is hydrogen, deuterium, alkyl, deuterated alkyl, heteroalkyl, haloalkyl, cycloalkyl, or heterocyclyl;
- and
- n is 0 or 1.
A compound, or derivative thereof, of Formula (II):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- R1, R2, R6, R7, and independently are hydrogen, deuterium, alkyl, deuterated alkyl, heteroalkyl, haloalkyl, cycloalkyl, or heterocyclyl;
- R4, R5, R8, and R9 independently are hydrogen, deuterium, alkyl, heteroalkyl, haloalkyl, cycloalkyl, CO2R11, CONHR11, CO2N(R11)(R12), CN, or halogen,
- wherein R11 and R12 independently are hydrogen, deuterium, heteroalkyl, haloalkyl, cycloalkyl, or heterocyclyl;
- R10 is hydrogen, deuterium, or alkyl;
- A is C or N;
- B is CR13, N, or CO,
- wherein R13 is hydrogen, deuterium, alkyl, heteroalkyl, haloalkyl, cycloalkyl, or heterocyclyl;
- E is CR3, NR3, N, O, or S;
- wherein R3 is hydrogen, deuterium, alkyl, deuterated alkyl, heteroalkyl, haloalkyl, cycloalkyl, or heterocyclyl;
- and
- n is 0 or 1.
A compound selected from:
Dependencies are inferred from the claim text.