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AssigneeWuhan Createrna Science and Technology Co., Ltd.
InventorsQinquan HU, Jun LOU, Liang WANG, Yihan ZHANG
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Disclosed in the present invention are crystal forms of a nitrogen-containing spiro compound, a preparation method therefor and the use thereof. Provided in the present invention are a crystal form I and a crystal form II of a nitrogen-containing spiro compound as shown in formula A. Herein, crystal form I has an X-ray powder diffraction pattern comprising diffraction peaks at 5.67±0.20°, 11.37±0.20°, 16.69±0.20°, 17.32±0.20° and 19.73±0.20° 2θ, as determined by using Cu-Kα radiation crystal form II has an X-ray powder diffraction pattern comprising diffraction peaks at 11.32±0.20°, 11.70±0.20°, 11.93±0.20°, 18.03±0.20°, 18.81±0.20° and 19.17±0.20° 2θ, as determined by using Cu-Kα radiation. The crystal forms of the nitrogen-containing spiro compound of the present invention have good stability, an inhibitory activity on complement factor D, a good inhibitory effect on rabbit erythrocyte hemolysis, and relatively high in-vivo exposure and relatively high oral bioavailability.
A crystal form I of a nitrogen-containing spiro compound of formula A, wherein the crystal form I has an X-ray powder diffraction pattern comprising diffraction peaks at 5.67±0.20°, 11.37±0.20°, 16.69±0.20°, 17.32±0.20°, and 19.73±0.20°, as determined by using Cu-Kα radiation and expressed in terms of 2θ angles;
A crystal form II of a nitrogen-containing spiro compound of formula A, wherein the crystal form II has an X-ray powder diffraction pattern comprising diffraction peaks at 11.32±0.20°, 11.70±0.20°, 11.93±0.20°, 18.03±0.20°, 18.81±0.20°, and 19.17±0.20°, as determined by using Cu-Kα radiation and expressed in terms of 2θ angles;
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Dependencies are inferred from the claim text.