Methods and devices for treating a disease with biotherapeutics

An ingestible device, comprising:

• a housing having a first housing part and a second housing part;
• a restraining mechanism comprising a degradable, erodible and/or dissolvable material;
• wherein the ingestible device is configured so that:
• when the restraining mechanism is in a first state, the restraining mechanism has sufficient strength to keep the first and second housing parts connected for storing a dispensable substance in the housing under pressure;
• and
• when the restraining mechanism is in a second state wherein the material is at least partially degraded, eroded and/or dissolved, the restraining mechanism allows the first and second housing parts to separate from each other sufficiently to dispense at least a portion of the dispensable substance.