Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods

A bone restorative composition comprising;

• (i) a multivalent metal phosphate compound,
• (ii) a polymer that contain esters, carbonyl, carbonate, carboxylic acids, amides, amine groups and mixtures thereof as the bonding sites of the polymer surfaces to the available metal ions,
• (iii) a compound of the formula;
• where A is O, CH2, or S;
• R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3 and wherein the compound is present in an amount greater than about 10% by weight based on the combined weight of the multivalent metal phosphate salt and the compound, and
• (iv) an aqueous medium.

A kit for restoring bone comprising;

• A) A first container containing a composition comprising:
• (i) a multivalent metal phosphate compound,
• (ii) a polymer that contain esters, carbonyl, carbonate, carboxylic acids, amides, amine groups and mixtures thereof as the bonding sites of the polymer surfaces to the available metal ions, and
• (iii) a compound of the formula;
• where A is O, CH2, or S;
• R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3 and wherein the compound is present in an amount greater than about 10% by weight based on the combined weight of the multivalent metal phosphate compound and the compound, and
• B) a second container containing an aqueous medium.

A method of adhering a material to a polymer comprising the steps of:

• placing a composition between the material and the polymer wherein the composition comprises:
• (i) a multivalent metal phosphate compound,
• (ii) a compound of the formula;
• where A is O, CH2, or S;
• R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3 and wherein the compound is present in an amount greater than about 10% by weight based on the combined weight of the multivalent metal phosphate salt and the compound, and
• an aqueous medium
• and
• allowing the composition to cure to form an interpenetrating network at the interface between the composition and the polymer,
• wherein the polymer contain esters, carbonyl, carbonate, carboxylic acids, amides, amine groups and mixtures thereof as the bonding sites of the polymer surfaces to the available metal ions, and wherein the composition adheres to the material.