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US 2026/0263652 A1Published application
Hydrogel formulations and methods of use thereof
AssigneeTempo Therapeutics, Inc.
InventorsStephanie DESHAYES, Westbrook WEAVER, Daria ANDRIYANOVA, Mitchell MCMAHON
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Abstract
Provided herein are hydrogel formulations and methods for the use thereof. In certain aspects, the methods comprise use of hydrogel formulations in the strengthening of a suture line at a suture line site.
Claims31
A method of delivering a hydrogel formulation to a site of a suture line in a subject, the method comprising:
- delivering to the suture line site of the subject the hydrogel formulation that anneals in situ to form a porous covalently stabilized scaffold, wherein endogenous cells infiltrate the porous covalently stabilized scaffold to form a cell matrix over the suture line site of the subject.
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A hydrogel system, comprising:
- a) microgel particles comprising a cross-linked 4-arm poly(ethylene glycol) (PEG) vinyl sulfone hydrogel polymer cross-linked with a matrix metalloprotease (MMP)-degradable crosslinker, one or more K-peptides and Q-peptides, and a cell-adhesive peptide, wherein the microgel particles are present in a suspension comprising the microgel particles and water, and the microgel particles are present in the suspension at a volume fraction of at least 90%;
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- b) PEG-dithiol, wherein the microgel particles undergo an annealing reaction to form a porous covalently stabilized scaffold after exposure to the PEG-dithiol, wherein the PEG-dithiol is present in the hydrogel system in a molar concentration of at least about 0.02 millimolar (mM) to about 1.0 mM.
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Dependencies are inferred from the claim text.