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US 2026/0263645 A1Published application
Multifunctional antibodies
AssigneeTelix Pharmaceuticals (Innovations) Pty Ltd.
InventorsKwame TWUMASI-BOATENG, Michael Paul WHEATCROFT, David CHIN
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Abstract
The invention relates to molecules comprising a tumour antigen binding protein and an extracellular domain (ECD) or ligand binding fragment of a transforming growth factor β receptor (TGFβR), and compositions and uses thereof.
Claims86
A molecule comprising a tumour antigen binding protein and an extracellular domain (ECD) or ligand binding fragment of a transforming growth factor β receptor (TGFβR).
A therapeutic IgG molecule comprising:
- heavy and light chains, wherein each chain comprises a variable region and a constant region, and at least one variable region binds a tumour antigen;
- a radioisotope conjugated to one or more amino acid residues of the heavy or light chains;
- and
- an extracellular domain (ECD) or ligand binding fragment of a transforming growth factor β receptor (TGFβR).
1 more element
Dependencies are inferred from the claim text.