Compositions for targeting muscle cells and uses thereof
AssigneesCavalry Biosciences, Inc., University of Florida Research Foundation, Inc.
InventorsNathaniel Eames DAVID, Robert N. O'BRIEN, Timothy R. STOWE, Patrick B. VENTURA, James W. WEST, Elisabeth BARTON
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Abstract
Disclosed herein are compositions that are useful for targeting a signaling pathway modulator to a muscle cell. In some instances, such compositions may be useful in treating a muscle disorder, such as muscular dystrophy.
Claims24
A method of increasing phosphorylated AKT (pAKT) in a muscle cell, the method comprising contacting the muscle cell with an agent comprising (a) an antigen-binding domain that selectively binds to a mammalian ITGA7 and (b) an IGF-1 polypeptide that is coupled to the antigen-binding domain.
A method of increasing muscle mass in a subject, the method comprising administering to the subject an agent comprising (a) an antigen-binding domain that selectively binds to a mammalian ITGA7 and (b) an IGF-1 polypeptide that is coupled to the antigen-binding domain.
Dependencies are inferred from the claim text.