US 2026/0263610 A1 · MURINE STEM CELL FACTOR POLYPEPTIDES, COMPOSITIONS, AND METHODS OF USE

Abstract

Provided herein are murine stem cell factor (mSCF) polypeptides, as well as compositions comprising the same, and methods of using the same. In some embodiments, the mSCF polypeptides are for use in treating one or more conditions in a human subject. Such conditions to be treated may include, but are not limited to, melanocyte dysfunction or deficiency, and processes associated with the same. The present disclosure also provides the use of such mSCF polypeptides for the treatment of hair loss and/or hair whitening.

Claims34

Dependent claims

A method of treating a condition of a human subject, the method comprising administering to the human subject a composition comprising one or more of a murine Stem Cell Factor (mSCF) polypeptide;

wherein:
(a) the mSCF polypeptide:
(i) is 5-60 amino acids in length;
and (ii) comprises the amino acid sequence of any one of SEQ ID NOs:
15-36 or 51-73;
and
(b) the treating comprises one or more of:
(i) inhibiting apoptosis of melanocytes or melanocyte stem cells (McSCs), (ii) increasing number or survival of melanocytes or McSCs, (iii) increasing a level of melanin synthesis, (iv) inhibiting hair whitening, (v) promoting increased hair pigmentation, (vi) inhibiting hair loss, or (vii) promoting increased hair growth;
as compared to the absence of said treating.

6 more elements

Dependencies are inferred from the claim text.

Murine stem cell factor polypeptides, compositions, and methods of use

Life of this patent

Murine stem cell factor polypeptides, compositions, and methods of use

Life of this patent

Abstract

Claims34