US 2026/0263575 A1 · MRNA THERAPEUTIC COMPOSITIONS

Abstract

Disclosed herein are mRNA therapeutic compositions including one or more polynucleotides encoding one or more tumor antigenic, immunogenic, or signaling polypeptides, formulated within a lipid reconstructed plant messenger packs (LPMPs) comprising natural lipids and an ionizable lipid. The disclosure also includes a method for making a mRNA therapeutic composition, comprising reconstituting a film comprising purified PMP lipids in the presence of an ionizable lipid to produce a LPMP comprising the ionizable lipid, and loading into the LPMPs with one or more polynucleotides encoding one or more tumor antigenic or immunogenic polypeptides.

Claims42

Dependent claims

An mRNA therapeutic composition, comprising:

one or more polynucleotides encoding one or more tumor antigenic or signaling polypeptides,
formulated within a lipid reconstructed plant messenger packs (LPMPs) comprising natural lipids and an ionizable lipid, wherein the ionizable lipid has two or more of the characteristics listed below:
(i) at least 2 ionizable amines;
(ii) at least 3 lipid tails;
wherein each of the lipid tails is at least 6 carbon atoms in length;
(iii) a pKa of about 4.5 to about 7.5;
(iv) an ionizable amine and a heteroorganic group separated by a chain of at least two atoms;
and
(v) an N:P ratio of at least 10.

6 more elements

Dependencies are inferred from the claim text.

Mrna therapeutic compositions

Life of this patent

Mrna therapeutic compositions

Life of this patent

Abstract

Claims42