Phage therapy utilizing a unique cocktail of pseudomonas aeruginosa phages

Abstract

In this disclosure, the genomes of five newly isolated lytic phages, which infect Pseudomonas aeruginosa, UF_RH1, UF_RH5, UF_RH6, UF_RH7, and UF_RH9 were sequenced, and a new phage cocktail comprising those phages was designed. When the anti P. aeruginosa activity of the phage cocktail was compared with an antibiotic, it was proved that the phage cocktail was at least as effective as the antibiotic. With an in vivo model of wax worm larvae, the phage cocktail increased the survival rate of the worms infected by bacteria. Based on these results, pharmaceutical compositions comprising any of the newly discovered phages or phage cocktail thereof is introduced as a novel antibacterial approach, and use methods thereof are also presented.

Dependencies are inferred from the claim text.