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AssigneeRohto Pharmaceutical Co., Ltd.
InventorsFlorence FLORENCE, Masatoshi HAGA, Yasunari SATO
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An object of the present invention is to provide a biomarker for use in determining skin aging, the biomarker containing a protein or a fragment thereof. Another object of the present invention is to provide a method for determining skin aging in a subject, the method being characterized by quantifying a protein or a fragment thereof in a blood sample from the subject. Yet another object of the present invention is to provide a method for screening a substance for improving skin aging, the method being characterized by examining a change in expression level or concentration of a protein or a fragment thereof in a blood sample from a subject before and after ingestion of a test substance by the subject. The present invention is directed to a biomarker for use in determining skin aging, the biomarker containing a protein or a fragment thereof, the protein being selected from the group consisting of osteomodulin (OMD), chondroadherin (CHAD), collagen type XI alpha 2 chain (COL11A2), leucine-rich repeat-containing protein 15 (LRRC15), Glycoprotein hormones alpha chain/Choriogonadotropin subunit beta 3/Choriogonadotropin subunit beta 7 (CGA/CGB3/CGB7), lutropin subunit beta (LHB), glycoprotein hormones alpha chain/lutropin subunit beta (CGA/LHB), and glycoprotein hormones alpha chain/follitropin subunit beta (CGA/FSHB).
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A method for determining skin aging in a subject, the method comprising quantifying at least one protein or a fragment thereof in a blood sample from the subject, the protein being selected from the group consisting of osteomodulin (OMD), chondroadherin (CHAD), collagen type XI alpha 2 chain (COL11A2), leucine-rich repeat-containing protein 15 (LRRC15), Glycoprotein hormones alpha chain/Choriogonadotropin subunit beta 3/Choriogonadotropin subunit beta 7 (CGA/CGB3/CGB7), lutropin subunit beta (LHB), glycoprotein hormones alpha chain/lutropin subunit beta (CGA/LHB), and glycoprotein hormones alpha chain/follitropin subunit beta (CGA/FSHB).
A method for screening a substance for improving skin aging, the method comprising examining a change in expression level or concentration of at least one protein or a fragment thereof in a blood sample from a subject before and after ingestion of a test substance by the subject, the protein being selected from the group consisting of osteomodulin (OMD), chondroadherin (CHAD), collagen type XI alpha 2 chain (COL11A2), leucine-rich repeat-containing protein 15 (LRRC15), Glycoprotein hormones alpha chain/Choriogonadotropin subunit beta 3/Choriogonadotropin subunit beta 7 (CGA/CGB3/CGB7), lutropin subunit beta (LHB), glycoprotein hormones alpha chain/lutropin subunit beta (CGA/LHB), and glycoprotein hormones alpha chain/follitropin subunit beta (CGA/FSHB).
Dependencies are inferred from the claim text.