Malt1 tumor inhibitor, pharmaceutical composition containing the same, and applications thereof

Abstract

The present invention provides a MALT1 tumor inhibitor. This inhibitor can inhibit the expression of the MALT1 gene or inactivate the function of the MALT1 protein. It is selected from agents that can affect the expression of the death domain of the MALT1 protein, agents that knockout the death domain, agents that alter the structure of the death domain, or agents that degrade the death domain. The MALT1 tumor inhibitor can effectively treat various solid tumors and can also treat tumors that are untreatable with immune checkpoint inhibitors. In addition, when used in combination with immune checkpoint inhibitors, it can exert a synergistic effect, and the therapeutic effect is significantly enhanced.

Dependencies are inferred from the claim text.