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US 2026/0257994 A1Published application
Isoindoline compositions and methods for treating neurodegenerative disease
AssigneeCognition Therapeutics, Inc.
InventorsGilbert M. RISHTON, Susan M. CATALANO, Gary C. LOOK
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Abstract
Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.
Claims7
-37. (canceled)
A pharmaceutical composition comprising about 0.01 mg/kg/day to about 25 mg/kg/day, of a compound of the Formula:
- or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or excipient.
Dependencies are inferred from the claim text.