Acetaminophen compositions and methods of treating cancer
AssigneesThe United States Government as represented by the Department of Veterans Affairs, Virginia Commonwealth University
InventorsAlexander Neuwelt, Allyn Bryan
Life of this patent
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Abstract
The disclosure relates to compositions including acetaminophen or analogs thereof and CYP2E1-inhibitors suitable for parenteral or oral administration. Methods of treating cancer in subjects by administering acetaminophen or analogs thereof and CYP2E1-inhibitors are also included.
Claims42
A composition comprising:
- acetaminophen or an analog thereof;
- and a CYP2E1 inhibitor.
A pharmaceutical liquid composition comprising:
- acetaminophen or an analog thereof;
- and a CYP2E1 inhibitor.
A method of reducing or inhibiting growth of a tumor in a subject, the method comprising administering to the subject a therapeutically effective amount of acetaminophen or an analog thereof and a therapeutically effective amount of a CYP2E1 inhibitor.
A method of inducing apoptosis of a cancer cell, the method comprising administering to the subject a therapeutically effective amount of acetaminophen or an analog thereof and a therapeutically effective amount of a CYP2E1 inhibitor.
A method of treating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of acetaminophen or an analog thereof and a therapeutically effective amount of a CYP2E1 inhibitor.
Dependencies are inferred from the claim text.