Compositions of and methods for a cold slurry having hyaluronic acid
AssigneeBrixton Biosciences, Inc.
InventorsSameer SABIR, Charles SIDOTI, Olivier KAGAN, Mansoor M. AMIJI, Joseph AARON, Danielle BRUCATO, Jun LI
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a composition comprising an amount of water; a hyaluronic acid; and a first excipient, wherein the composition is configured to be formed into a ‘flowable cold slum’ when the composition is exposed, to a temperature of 0° C. or less.
Claims85
A composition comprising:
- an amount of water;
- a hyaluronic acid;
- and
- a first excipient, wherein the composition is configured to be formed into a flowable cold slurry comprising a plurality of ice crystals when the composition is exposed to a temperature of 0° C or less.
A method of preparing a cold slurry for administration to a patient at a clinical point of care, the method comprising:
- preparing a composition comprising a hyaluronic acid and an amount of water;
- adding a first excipient to the composition, wherein the excipient comprises a water-soluble surfactant;
- and
- wherein the composition is configured to form a cold slurry comprising a plurality of ice particles when the composition is cooled to a temperature below about 0° C.
A method of preparing a cold slurry for administration to a patient at a clinical point of care, the method comprising:
- receiving a composition comprising a freezing point depressant and a hyaluronic acid;
- and
- cooling the composition to a temperature below about 0° C. to form a cold slurry, wherein the cold slurry comprises a plurality of ice particles.
A cold slurry delivery system comprising:
- a container holding a slurry composition, the container comprising a sterile barrier and a temperature indicator, wherein the container is configured to allow manual agitation of the slurry composition without breaking the sterile barrier.
Dependencies are inferred from the claim text.