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AssigneesAltos Labs, Inc., Hospital Clinic De Barcelona
InventorsJuan Carlos IZPISUA BELMONTE, Pradeep Reddy DUBBAKA VENU, Yosu LUQUE, Concepcion RODRIGUEZ ESTEBAN, Josep Maria CAMPISTOL PLANA
Estimating the term…
Provided are materials and methods for rejuvenating an ex vivo organ prior to transplantation of the organ into a subject in need thereof. The methods and materials can be used to treat, ameliorate, rejuvenate, and/or regenerate organs, e.g., kidneys and livers, that are of old age and/or characterized by organ damage due to an ischemic injury, a toxic injury, a perfusion injury, a hypertensive injury, an immune injury, a physical injury, steatosis, virus induced hepatitis, alcohol, or fibrosis not associated with any known cause. The materials and methods provided can increase the pool of available donor organs, e.g., kidneys and livers. Furthermore, the materials and methods provided can treat an organ that is then self-transplanted.
An organ perfusate comprising a first polynucleotide encoding at least one regeneration factor and at least one vasodilator.
A method of ex vivo rejuvenation of an organ, the method comprising:
A method of transplanting an organ into a subject in need thereof, the method comprising:
The method of 44, wherein the intermittent addition of the compound is repeated 2-10 times.
A method of transplanting an organ into a subject in need thereof, the method comprising:
An ex vivo organ for transplantation to a subject in need thereof, the ex vivo organ comprising:
Dependencies are inferred from the claim text.