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US 2026/0250781 A1Published application
Methods for early detection of cancer
AssigneeGuardant Health, Inc.
InventorsStefanie Ann Ward MORTIMER, AmirAli TALASAZ, Darya CHUDOVA, Helmy ELTOUKHY
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Abstract
Disclosed herein are methods, compositions, and devices for use in the early detection of cancer. The methods include preparing cell-free nucleic acid molecules from a subject for sequencing, sequencing a panel of regions in the cell-free nucleic acid molecules, and detecting one or more markers that are indicative of a cancer.
Claims20
A method for monitoring cancer in a subject, comprising:
- (a) providing a sample comprising cell-free deoxyribonucleic acid (cfDNA) molecules from a subject;
- (b) performing amplification-based enrichment of the cfDNA molecules or amplicons thereof for a plurality of genes or genomic regions to generate a sequencing panel, wherein the plurality of genes or genomic regions:
- (i) comprise CpG islands which are differentially methylated regions, and
- (ii) are selected without using prior knowledge from a tumor of the subject;
- (c) sequencing a plurality of enriched cfDNA molecules or enriched amplicons thereof to generate sequencing data;
- and
- (d) determining methylation profiles of the cfDNA molecules from the sequencing data to monitor the cancer in the subject.
4 more elements
Dependencies are inferred from the claim text.