Tcr molecule targeting kras g12v mutation, cell, and uses thereof

A binding protein, comprising a binding domain having antigen specificity for an antigen peptide:

• HLA complex, wherein the binding domain comprises a T cell receptor (TCR) α chain variable region and a TCR β chain variable region, wherein:
• the antigen peptide comprises an amino acid sequence of VVGAVGVGK (SEQ ID NO:
• 91);
• the HLA is HLA-A*11:01;
• CDR3 of the α chain variable region comprises the amino acid sequence of SEQ ID NO:
• 65, 5, 15, 25, 35, 45, 55, 75, or 85, or an amino acid sequence having at least 80% identity or 90% identity to the amino acid sequence of SEQ ID NO:
• 65, 5, 15, 25, 35, 45, 55, 75, or 85;
• CDR3 of the β chain variable region comprises the amino acid sequence of SEQ ID NO:
• 70, 10, 20, 30, 40, 50, 60, 70, 80, or 90, or an amino acid sequence having at least 80% identity or 90% identity to the amino acid sequence of SEQ ID NO:
• 70, 10, 20, 30, 40, 50, 60, 80, or 90.